{"id":676,"date":"2025-08-22T20:39:19","date_gmt":"2025-08-22T20:39:19","guid":{"rendered":"https:\/\/demo26.mystagingserver.site\/moheb\/?page_id=676"},"modified":"2025-08-22T20:47:44","modified_gmt":"2025-08-22T20:47:44","slug":"neurodia","status":"publish","type":"page","link":"https:\/\/demo26.mystagingserver.site\/moheb\/neurodia\/","title":{"rendered":"neuroDia"},"content":{"rendered":"\t\t
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neuroDia<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Over 20 million Americans are estimated to have some form of\u00a0peripheral neuropathy,<\/b><\/strong>\u00a0a nerve disease that can lead to pain, numbness, and weakness, most often in the hands, feet, and legs.<\/p>

Peripheral neuropathy has different causes, with\u00a0diabetes<\/b><\/strong>\u00a0and blood vessel problems notable among them.1<\/sup><\/p>

As it worsens,\u00a0diabetic peripheral neuropathy<\/b><\/strong>\u00a0may lead to the development of foot ulcers and the need for foot or leg amputations.2<\/sup>\u00a0People with peripheral neuropathy also have higher rates of\u00a0overall mortality<\/b><\/strong>.3<\/sup><\/p>

But there\u2019s good news. A nutrient called\u00a0lipoic acid<\/b><\/strong>\u00a0has been successfully used for the treatment of diabetic neuropathy in Germany for decades.4,5<\/sup><\/p>

Clinical trials in people suffering from\u00a0diabetic neuropathy<\/b><\/strong>\u00a0show that\u00a0lipoic acid\u00a0<\/b><\/strong>can reduce\u00a0pain<\/b><\/strong>\u00a0and other symptoms,6-9<\/sup>\u00a0and may help prevent progression of nerve damage.9<\/sup><\/p>

What Is Peripheral Neuropathy?<\/p>

Peripheral Neuropathy\u00a0is a general term for disease of the nerves outside the brain and spinal cord.10<\/sup><\/p>

Peripheral neuropathies, diabetic2,11<\/sup>\u00a0or non-diabetic, often begin in the feet, and often progress up the leg over time.1,12<\/sup><\/p>

Among other conditions that affect nerves, the most common culprit is\u00a0high blood sugar, which is why people with type II diabetes have the\u00a0highest<\/i><\/em>\u00a0rates of neuropathy.2,13<\/sup><\/p>

Estimates of the prevalence of peripheral neuropathy in diabetics range as high as\u00a070%<\/b><\/strong>.1<\/sup><\/p>

In adults\u00a0without<\/i><\/em>\u00a0diabetes, peripheral neuropathy occurs much less frequently than in those with diabetes.13<\/sup>\u00a0Alcohol abuse,13<\/sup>\u00a0some chemotherapy drugs,13<\/sup>\u00a0hereditary diseases,\u00a0vitamin B12\u00a0deficiency, and other health conditions can contribute to or cause its development.1,14<\/sup><\/p>

Peripheral neuropathy<\/b><\/strong>\u00a0often results in loss of function, numbness, tingling, and extreme pain.12<\/sup><\/p>

Eventually, it may result in loss of balance.10<\/sup>\u00a0Diabetic neuropathy may result in difficulty walking and increased risk of falls.5<\/sup><\/p>

Diabetic neuropathy is the major cause of diabetic\u00a0foot ulcers<\/b><\/strong>\u00a0and\u00a0infections<\/b><\/strong>, which can lead to leg\u00a0amputations<\/b><\/strong>.2,13<\/sup>\u00a0A large, clinical study showed lower-limb amputation rates in those with\u00a0diabetes were\u00a015 times<\/b><\/strong>\u00a0higher than in non-diabetics.15<\/sup><\/p>

Neuropathy in diabetics can also affect nerves that control heart and blood vessels, causing abnormalities of heart rate and blood vessel function.\u00a0Cardiac autonomic neuropathy<\/b><\/strong>\u00a0can be associated with a high risk of arrhythmias, and sudden cardiac death.16,17<\/sup><\/p>

One large study found that peripheral neuropathy is an independent predictor of\u00a0higher<\/i><\/em>\u00a0overall mortality<\/b><\/strong>.\u00a03<\/sup><\/p>

Lipoic Acid Defends Nerves<\/p>

Lipoic acid<\/b><\/strong>\u00a0is a compound produced in the body and also found in small amounts in some vegetables and animal products, particularly organ meats.17<\/sup><\/p>

It plays an essential role in turning glucose and other nutrients into energy.18<\/sup>\u00a0It enhances glucose uptake,20<\/sup>\u00a0and plays a role in modulating\u00a0insulin sensivitivy.20<\/sup><\/p>

It is also a potent\u00a0antioxidant<\/b><\/strong>\u00a0that helps fight oxidative stress. It even helps regenerate several\u00a0other<\/i><\/em>\u00a0antioxidants.12,21<\/sup><\/p>

One review reported that lipoic acid can help decrease pain signals by blocking channels on pain-sensing nerve cells.5<\/sup><\/p>

Lipoic acid has been licensed and used in the management of\u00a0diabetic peripheral neuropathy<\/b><\/strong>\u00a0for decades in Germany.\u00a05<\/sup><\/p>

Easing Pain and Improving Function<\/b><\/strong><\/p>

Scientists have conducted many clinical trials of\u00a0lipoic acid<\/b><\/strong>\u00a0for diabetic peripheral neuropathy.6-9,17<\/sup><\/p>

Nerve conduction studies, which measure how efficiently electrical signals move through a nerve, have shown that lipoic acid can\u00a0improve nerve function. Nerve conduction velocities that were previously slowed were boosted with lipoic acid use.8<\/sup><\/p>

Additional benefits have been identified in other trials.<\/p>

For example, a clinical study in diabetics found that lipoic acid not only improved peripheral neuropathy scores, it also significantly decreased feelings of\u00a0depression.9<\/sup>\u00a0Diabetics are two to three times more likely than non-diabetics to have depression.22<\/sup><\/p>

Another clinical study found that\u00a050%<\/b><\/strong>\u00a0of subjects felt their\u00a0quality of life<\/b><\/strong>\u00a0and\u00a0overall health\u00a0<\/b><\/strong>condition was \u201cvery much better\u201d or \u201cmuch better\u201d following 40 days of lipoic acid supplementation.6<\/sup><\/p>

Studies have shown that lipoic acid led to improvements in potentially deadly\u00a0cardiac autonomic neuropathy<\/b><\/strong>\u00a0as well.8,23<\/sup><\/p>

Lipoic acid use has also been associated with improvements in body mass index,5,8,24<\/sup>\u00a0cholesterol levels,6<\/sup>\u00a0and markers of blood glucose control.8,23<\/sup><\/p>

Peripheral neuropathy<\/b><\/strong>\u00a0is a common condition that causes numbness, tingling, pain, and loss of function in the peripheral nerves. In diabetics, it is associated with an increased risk of amputations, falls, and death.<\/p>

Lipoic acid<\/b><\/strong>\u00a0has been used to treat diabetic peripheral neuropathy in Germany for decades.<\/p>

Clinical studies show that it can lead to significant reductions in pain, numbness, and other symptoms.<\/p>

References<\/p>

  1. Available at:\u00a0https:\/\/www.ninds.nih.gov\/peripheral-neuropathy-fact-sheet<\/b><\/u><\/strong><\/a>. Accessed January, 9, 2023.<\/li>
  2. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes.\u00a0Curr Diab Rep.<\/i><\/em>2019 Aug 27;19(10):86.<\/li>
  3. Hicks CW, Wang D, Matsushita K, et al. Peripheral Neuropathy and All-Cause and Cardiovascular Mortality in U.S. Adults : A Prospective Cohort Study.\u00a0Ann Intern Med.<\/i><\/em>2021 Feb;174(2):167-74.<\/li>
  4. Ziegler D, Reljanovic M, Mehnert H, et al. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.\u00a0Exp Clin Endocrinol Diabetes.<\/i><\/em>1999;107(7):421-30.<\/li>
  5. Nguyen N, Takemoto JK. A Case for Alpha-Lipoic Acid as an Alternative Treatment for Diabetic Polyneuropathy.\u00a0J Pharm Pharm Sci.<\/i><\/em>2018;21(1s):177s-91s.<\/li>
  6. Agathos E, Tentolouris A, Eleftheriadou I, et al. Effect of alpha-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy.\u00a0J Int Med Res.<\/i><\/em>2018 May;46(5):1779-90.<\/li>
  7. El-Nahas MR, Elkannishy G, Abdelhafez H, et al. Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.\u00a0Endocr Metab Immune Disord Drug Targets.<\/i><\/em>2020;20(9):1531-4.<\/li>
  8. Elbadawy AM, Abd Elmoniem RO, Elsayed AM. Alpha lipoic acid and diabetes mellitus: potential effects on peripheral neuropathy and different metabolic parameters.\u00a0Alexandria Journal of Medicine.<\/i><\/em>2021;57(1):113-20.<\/li>
  9. Karalis DT, Karalis T, Karalis S, et al. The Effect of Alpha-Lipoic Acid on Diabetic Peripheral Neuropathy and the Upcoming Depressive Disorders of Type II Diabetics.\u00a0<\/i>2021 Jan 18;13(1):e12773.<\/li>
  10. Available at:\u00a0https:\/\/www.hopkinsmedicine.org\/health\/conditions-and-diseases\/peripheral-neuropathy#:~:text=The%20most%20common%20type%20of,as%20burning%20pain%20or%20paralysis<\/b><\/u><\/strong><\/a>. Accessed January, 9, 2023.<\/li>
  11. Deli G, Bosnyak E, Pusch G, et al. Diabetic neuropathies: diagnosis and management.\u00a0<\/i>2013;98(4):267-80.<\/li>
  12. Available at:\u00a0https:\/\/www.statpearls.com\/articlelibrary\/viewarticle\/25827<\/b><\/u><\/strong><\/a>. Accessed January, 12, 2023.<\/li>
  13. Hicks CW, Wang D, Windham BG, et al. Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts.\u00a0Sci Rep.<\/i><\/em>2021 Sep 27;11(1):19159.<\/li>
  14. Staff NP, Windebank AJ. Peripheral neuropathy due to vitamin deficiency, toxins, and medications.\u00a0Continuum (Minneap Minn).<\/i><\/em>2014 Oct;20(5 Peripheral Nervous System Disorders):1293-306.<\/li>
  15. Kamitani F, Nishioka Y, Noda T, et al. Incidence of lower limb amputation in people with and without diabetes: a nationwide 5-year cohort study in Japan.\u00a0BMJ Open.<\/i><\/em>2021 Aug 17;11(8):e048436.<\/li>
  16. Agashe S, Petak S. Cardiac Autonomic Neuropathy in Diabetes Mellitus.\u00a0Methodist Debakey Cardiovasc J.<\/i><\/em>2018 Oct-Dec;14(4):251-6.<\/li>
  17. Serhiyenko VA, Serhiyenko AA. Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment.\u00a0World J Diabetes.<\/i><\/em>2018 Jan 15;9(1):1-24.<\/li>
  18. Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling.\u00a0J Clin Biochem Nutr.<\/i><\/em>2011 Jan;48(1):26-32.<\/li>
  19. Golbidi S, Badran M, Laher I. Diabetes and alpha lipoic Acid.\u00a0Front Pharmacol.<\/i><\/em>2011;2:69.<\/li>
  20. Ansar H, Mazloom Z, Kazemi F, et al. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.\u00a0Saudi Med J.<\/i><\/em>2011 Jun;32(6):584-8.<\/li>
  21. Available at:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK564301\/#!po=91.6667<\/b><\/u><\/strong><\/a>. Accessed 12\/05\/2022,<\/li>
  22. Available at:\u00a0https:\/\/www.cdc.gov\/diabetes\/managing\/mental-health.html<\/b><\/u><\/strong><\/a>. Accessed January, 12, 2023.<\/li>
  23. Serhiyenko VA, Serhiyenko LM, Sehin VB, et al. Effect of alpha-lipoic acid on arterial stiffness parameters in type 2 diabetes mellitus patients with cardiac autonomic neuropathy.\u00a0Endocr Regul.<\/i><\/em>2021 Dec 7;55(4):224-33.<\/li>
  24. Namazi N, Larijani B, Azadbakht L. Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials.\u00a0Clin Nutr.<\/i><\/em>2018 Apr;37(2):419-28.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
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    neuroDia TM Over 20 million Americans are estimated to have some form of\u00a0peripheral neuropathy,\u00a0a nerve disease that can lead to pain, numbness, and weakness, most often in the hands, feet, and legs. Peripheral neuropathy has different causes, with\u00a0diabetes\u00a0and blood vessel problems notable among them.1 As it worsens,\u00a0diabetic peripheral neuropathy\u00a0may lead to the development of foot […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-676","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/pages\/676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/comments?post=676"}],"version-history":[{"count":6,"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/pages\/676\/revisions"}],"predecessor-version":[{"id":692,"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/pages\/676\/revisions\/692"}],"wp:attachment":[{"href":"https:\/\/demo26.mystagingserver.site\/moheb\/wp-json\/wp\/v2\/media?parent=676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}